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ICAM-1, VCAM-1, and selectins; induces MCP-1 expression in endothelium; attenuates NO production by downregulating NOS expression; increase expression and activity of PAI-1 IL-6 adipocytes, hepatocytes, activated Th 2 cells, and antigen-presenting cells (APCs) acute phase response, B cell proliferation, thrombopoiesis, synergistic with IL-1 and TNF on T cells Leptin predominantly adipocytes, mammary gland, intestine, muscle, placenta see Adipose Tissue page monocyte chemotactic protein-1 (MCP-1) leukocytes, adipocytes is a chemokine defined as CCL2 (C-C motif, ligand 2); recruits monocytes, T cells, and dendritic cells to sites of infection and tissue injury plasminogen-activator inhibitor-1 (PAI-1) adipocytes, monocytes, placenta, platelets, endometrium see the Blood Coagulation page for more details Resistin adipocytes, spleen, monocytes, macrophages, lung, kidney, bone marrow, placenta see Adipose Tissue page TNFα primarily activated macrophages, adipocytes induces expression of other autocrine growth factors, increases cellular responsiveness to growth factors and induces signaling pathways that lead to proliferation. 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